Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: a pilot trial
نویسندگان
چکیده
منابع مشابه
Concurrent Whole Brain Radiotherapy and Short-course Chloroquine in Patients with Brain Metastases: a Pilot Trial.
OBJECTIVE The immune modulatory drug chloroquine (CQ) has been demonstrated to enhance survival following radiotherapy in patients with high-grade glioma in a clinical trial, but the efficacy in patients with brain metastases is unknown. We hypothesized that short-course CQ during whole brain radiotherapy (WBRT) would improve response to local therapy in patients with brain metastases. METHOD...
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Background: Palliative whole brain radiotherapy (WBRT) has been the standard treatment for brain metastases. Ionizing radiation is known to be one of the most potent cataractogenic agents. We aimed to evaluate two different radiotherapy techniques with respect to the doses received by the organs at risk (OAR) in patients with brain metastasis who undergone WBRT. Materials and Methods: Ten conse...
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OBJECTIVE We performed a meta-analysis of randomized clinical trials to compare the efficacy of brain radiotherapy (RT) combined with temozolomide (TMZ) versus RT alone as first-line treatment for brain metastases (BM). METHODS Medline, Embase, and Pubmed were used to search for relevant randomized controlled trials (RCTs). Two investigators reviewed the abstracts and independently rated the ...
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ژورنال
عنوان ژورنال: Journal of Radiation Oncology
سال: 2013
ISSN: 1948-7894,1948-7908
DOI: 10.1007/s13566-013-0111-x